In:
Human Genome Variation, Springer Science and Business Media LLC, Vol. 2, No. 1 ( 2015-09-17)
Abstract:
Narcolepsy without cataplexy (NA w/o CA) (narcolepsy type 2) is a lifelong disorder characterized by excessive daytime sleepiness and rapid eye movement (REM) sleep abnormalities, but no cataplexy. In the present study, we examined the human leukocyte antigen HLA-DQB1 in 160 Japanese patients with NA w/o CA and 1,418 control subjects. Frequencies of DQB1*06:02 were significantly higher in patients with NA w/o CA compared with controls (allele frequency: 16.6 vs. 7.8%, P =1.1×10 −7 , odds ratio (OR)=2.36; carrier frequency: 31.3 vs. 14.7%, P =7.6×10 −8 , OR=2.64). Distributions of HLA-DQB1 alleles other than DQB1*06:02 were compared between NA w/o CA and narcolepsy with cataplexy (NA-CA) to assess whether the genetic backgrounds of the two diseases have similarities. The distribution of the HLA-DQB1 alleles in DQB1*06:02 -negative NA w/o CA was significantly different from that in NA-CA ( P =5.8×10 −7 ). On the other hand, the patterns of the HLA-DQB1 alleles were similar between DQB1*06:02 -positive NA w/o CA and NA-CA. HLA-DQB1 analysis was also performed in 186 Japanese patients with idiopathic hypersomnia (IHS) with/without long sleep time, but no significant associations were observed.
Type of Medium:
Online Resource
ISSN:
2054-345X
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2015
detail.hit.zdb_id:
2863697-1