In:
Molecular Systems Biology, EMBO, Vol. 6, No. 1 ( 2010-01)
Abstract:
Besides the estrogen receptor response elements (EREs), estrogen receptor‐α binding is augmented by FOXA1 co‐binding, the presence of the histone mark, histone 3 monomethylated at the lysine 4 position and the presence of open chromatin. The major determinant of ER binding is the strength of the ERE. The differences in estrogen receptor‐binding profiles between breast cancer cell lines appear to be at sites with less ‘attractive’ EREs but modulated by the non‐sequence factors.
Type of Medium:
Online Resource
ISSN:
1744-4292
,
1744-4292
DOI:
10.1038/msb.2010.109
Language:
English
Publisher:
EMBO
Publication Date:
2010
detail.hit.zdb_id:
2193510-5
SSG:
12