In:
Molecular Systems Biology, EMBO, Vol. 6, No. 1 ( 2010-01)
Abstract:
We present HepatoNet1, a manually curated large‐scale metabolic network of the human hepatocyte that encompasses 〉 2500 reactions in six intracellular and two extracellular compartments. Using constraint‐based modeling techniques, the network has been validated to replicate numerous metabolic functions of hepatocytes corresponding to a reference set of diverse physiological liver functions. Taking the detoxification of ammonia and the formation of bile acids as examples, we show how these liver‐specific metabolic objectives can be achieved by the variable interplay of various metabolic pathways under varying conditions of nutrients and oxygen availability.
Type of Medium:
Online Resource
ISSN:
1744-4292
,
1744-4292
Language:
English
Publisher:
EMBO
Publication Date:
2010
detail.hit.zdb_id:
2193510-5
SSG:
12