In:
Molecular Systems Biology, EMBO, Vol. 9, No. 1 ( 2013-01)
Kurzfassung:
A systems analysis of immune biomarkers in 89 young and older adults revealed age‐dependent and age‐independent features, including markers of apoptosis that correlated with antibody responses to a seasonal influenza vaccine. image Influenza hemagglutinin peptide arrays reveal age‐associated effects that correlate with both pre‐existing and vaccine‐induced antibody titers. Age‐dependent and age‐independent baseline immune parameters correlate with and substantially predict the serological response to a seasonal influenza vaccine. Soluble FasL and gene modules associated with apoptosis are predictors of the serological response to an influenza vaccine, which was abrogated in Fas‐deficient mice.
Materialart:
Online-Ressource
ISSN:
1744-4292
,
1744-4292
Sprache:
Englisch
Verlag:
EMBO
Publikationsdatum:
2013
ZDB Id:
2193510-5
SSG:
12