In:
Nature Communications, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2016-08-02)
Abstract:
Synaptic adhesion molecules regulate various aspects of synapse development, function and plasticity. These functions mainly involve trans -synaptic interactions and positive regulations, whereas cis -interactions and negative regulation are less understood. Here we report that SALM4, a member of the SALM/Lrfn family of synaptic adhesion molecules, suppresses excitatory synapse development through cis inhibition of SALM3, another SALM family protein with synaptogenic activity. Salm4 -mutant ( Salm4 −/− ) mice show increased excitatory synapse numbers in the hippocampus. SALM4 cis -interacts with SALM3, inhibits trans -synaptic SALM3 interaction with presynaptic LAR family receptor tyrosine phosphatases and suppresses SALM3-dependent presynaptic differentiation. Importantly, deletion of Salm3 in Salm4 −/− mice ( Salm3 −/− ; Salm4 −/− ) normalizes the increased excitatory synapse number. These results suggest that SALM4 negatively regulates excitatory synapses via cis inhibition of the trans -synaptic SALM3–LAR adhesion.
Type of Medium:
Online Resource
ISSN:
2041-1723
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2016
detail.hit.zdb_id:
2553671-0
