In:
Nature Communications, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2017-02-14)
Abstract:
The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with P combined 〈 3 × 10 −8 ): 1q42.2 (rs12129938 in PCNXL2 ), 3q26.2 (rs6793295 a missense mutation in LRCC34 near TERC ), 5q22.1 (rs73227498 between NREP and EPB41L4A ), 10q24.33 (rs7902587 near OBFC1 ), and two independently associated variants at 15q22.33 (rs2289261 and rs56062135; both in SMAD3 ). We also confirm recently published association results from a Chinese study of a variant on 5p15.33 (rs2736100 near the TERT gene) and present a stronger association result for a moderately correlated variant (rs10069690; OR=1.20, P=3.2 × 10 −7 ) based on our study of individuals of European ancestry. In combination, these results raise several opportunities for future studies of the pathogenesis of thyroid cancer.
Type of Medium:
Online Resource
ISSN:
2041-1723
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2017
detail.hit.zdb_id:
2553671-0