In:
Nature Precedings, Springer Science and Business Media LLC
Abstract:
Gene Ontology (GO) provides a controlled vocabulary, which is used by several groups around the world to provide functional annotation to proteins across a wide range of species ("www.geneontology.org":http://www.geneontology.org). The BHF-UCL team is funded by the British Heath Foundation to supply GO annotation specifically for human proteins involved in cardiovascular (CV) processes. This is the first time that a physiological process-centered approach has been used for human protein GO annotation. Experienced GO curators from the BHF-UCL team work alongside the bench scientists from the CV genetics group at University College London. By working in a CV dedicated environment the GO curators are able to build up their expertise in the CV field. Over 4000 proteins have been identified as being cardiovascular related and over the last 14 months, the BHF-UCL team has added 6840 Gene Ontology annotations to 603 human CV related proteins, including CDKN2A, CDKN2B, EDN2, GH1 and TERF1. In order to provide detailed annotations the BHF-UCL GO curators also initiate the development of new GO terms related to cardiovascular processes. The development of these terms, such as lipoprotein-mediated signalling, regulation of cardiac muscle hypertrophy and cardiac epithelial to mesenchymal transition, are made in collaboration with the GO editorial office and CV scientists. We will present details of the progress made in the first year of the BHF-UCL GO annotation project and the impact on microarray analysis.
Type of Medium:
Online Resource
ISSN:
1756-0357
DOI:
10.1038/npre.2009.3135.1
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2009
detail.hit.zdb_id:
2637018-9
