In:
Oncogenesis, Springer Science and Business Media LLC, Vol. 9, No. 9 ( 2020-09-18)
Abstract:
The essential G 1 -cyclin, CCND1 , is a collaborative nuclear oncogene that is frequently overexpressed in cancer. D-type cyclins bind and activate CDK4 and CDK6 thereby contributing to G 1 –S cell-cycle progression. In addition to the nucleus, herein cyclin D1 was also located in the cytoplasmic membrane. In contrast with the nuclear-localized form of cyclin D1 (cyclin D1 NL ), the cytoplasmic membrane-localized form of cyclin D1 (cyclin D1 MEM ) induced transwell migration and the velocity of cellular migration. The cyclin D1 MEM was sufficient to induce G 1 –S cell-cycle progression, cellular proliferation, and colony formation. The cyclin D1 MEM was sufficient to induce phosphorylation of the serine threonine kinase Akt (Ser473) and augmented extranuclear localized 17β-estradiol dendrimer conjugate (EDC)-mediated phosphorylation of Akt (Ser473). These studies suggest distinct subcellular compartments of cell cycle proteins may convey distinct functions.
Type of Medium:
Online Resource
ISSN:
2157-9024
DOI:
10.1038/s41389-020-00266-y
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2020
detail.hit.zdb_id:
2674437-5
