In:
Translational Psychiatry, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2019-02-04)
Kurzfassung:
We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping ( N = 9), genome-wide SNP arrays ( N = 418), whole-exome sequencing ( N = 26), and whole-genome sequencing ( N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.
Materialart:
Online-Ressource
ISSN:
2158-3188
DOI:
10.1038/s41398-019-0414-9
Sprache:
Englisch
Verlag:
Springer Science and Business Media LLC
Publikationsdatum:
2019
ZDB Id:
2609311-X
