In:
Blood Cancer Journal, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-05-22)
Abstract:
Patients with MYC rearranged ( MYC -R) diffuse large B-cell lymphoma (DLBCL) have a poor prognosis. Previously, we demonstrated in a single-arm phase II trial (HOVON-130) that addition of lenalidomide to R-CHOP (R2CHOP) is well-tolerated and yields similar complete metabolic remission rates as more intensive chemotherapy regimens in literature. In parallel with this single-arm interventional trial, a prospective observational screening cohort (HOVON-900) was open in which we identified all newly diagnosed MYC -R DLBCL patients in the Netherlands. Eligible patients from the observational cohort that were not included in the interventional trial served as control group in the present risk-adjusted comparison. R2CHOP treated patients from the interventional trial ( n = 77) were younger than patients in the R-CHOP control cohort ( n = 56) (median age 63 versus 70 years, p = 0.018) and they were more likely to have a lower WHO performance score ( p = 0.013). We adjusted for differences at baseline using 1:1 matching, multivariable analysis, and weighting using the propensity score to reduce treatment-selection bias. These analyses consistently showed improved outcome after R2CHOP with HRs of 0.53, 0.51, and 0.59, respectively, for OS, and 0.53, 0.59, and 0.60 for PFS. Thus, this non-randomized risk-adjusted comparison supports R2CHOP as an additional treatment option for MYC -R DLBCL patients.
Type of Medium:
Online Resource
ISSN:
2044-5385
DOI:
10.1038/s41408-023-00854-2
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2023
detail.hit.zdb_id:
2600560-8
