In:
Nature Communications, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2018-03-07)
Kurzfassung:
Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 controls with a follow-up in up to 4,850 cases and 451,731 controls of European ancestry. We identify two new AS loci, on chromosome 1p21 near PALMD (rs7543130; odds ratio (OR) = 1.20, P = 1.2 × 10 −22 ) and on chromosome 2q22 in TEX41 (rs1830321; OR = 1.15, P = 1.8 × 10 −13 ). Rs7543130 also associates with bicuspid aortic valve (BAV) (OR = 1.28, P = 6.6 × 10 −10 ) and aortic root diameter ( P = 1.30 × 10 −8 ), and rs1830321 associates with BAV (OR = 1.12, P = 5.3 × 10 −3 ) and coronary artery disease (OR = 1.05, P = 9.3 × 10 −5 ). The results implicate both cardiac developmental abnormalities and atherosclerosis-like processes in the pathogenesis of AS. We show that several pathways are shared by CAD and AS. Causal analysis suggests that the shared risk factors of Lp(a) and non-high-density lipoprotein cholesterol contribute substantially to the frequent co-occurence of these diseases.
Materialart:
Online-Ressource
ISSN:
2041-1723
DOI:
10.1038/s41467-018-03252-6
Sprache:
Englisch
Verlag:
Springer Science and Business Media LLC
Publikationsdatum:
2018
ZDB Id:
2553671-0
