In:
Nature Communications, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2021-02-10)
Kurzfassung:
Daytime napping is a common, heritable behavior, but its genetic basis and causal relationship with cardiometabolic health remain unclear. Here, we perform a genome-wide association study of self-reported daytime napping in the UK Biobank ( n = 452,633) and identify 123 loci of which 61 replicate in the 23andMe research cohort ( n = 541,333). Findings include missense variants in established drug targets for sleep disorders ( HCRTR1 , HCRTR2 ), genes with roles in arousal ( TRPC6 , PNOC ), and genes suggesting an obesity-hypersomnolence pathway ( PNOC, PATJ ). Association signals are concordant with accelerometer-measured daytime inactivity duration and 33 loci colocalize with loci for other sleep phenotypes. Cluster analysis identifies three distinct clusters of nap-promoting mechanisms with heterogeneous associations with cardiometabolic outcomes. Mendelian randomization shows potential causal links between more frequent daytime napping and higher blood pressure and waist circumference.
Materialart:
Online-Ressource
ISSN:
2041-1723
DOI:
10.1038/s41467-020-20585-3
Sprache:
Englisch
Verlag:
Springer Science and Business Media LLC
Publikationsdatum:
2021
ZDB Id:
2553671-0
