In:
npj Regenerative Medicine, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2022-06-16)
Abstract:
The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors ( Egr1, Irf1, FosB ) that drives molecular and functional differences between old and young states. Overall, by dissecting the molecular signature of aged ISCs, our study identified transcription factors that enhance the regenerative capacity of ISCs.
Type of Medium:
Online Resource
ISSN:
2057-3995
DOI:
10.1038/s41536-022-00226-7
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2022
detail.hit.zdb_id:
2879698-6