In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-11-08)
Abstract:
Infant colic is a distressing condition of unknown etiology. An aberrant gastrointestinal microbiota has been associated, and Lactobacillus reuteri supplementation has been shown to reduce crying and/or fussing time (‘crying time’) in some infants with colic. The relationship between L . reuteri gut colonization and crying time has not been examined. We investigated the relationship between L . reuteri colonization and fecal microbiota (microbial diversity and Escherichia coli ), intestinal inflammation, and crying time in infants with colic, using a subset of 65 infants from the Baby Biotics trial, which randomized healthy term infants aged 〈 13 weeks with infant colic to receive probiotic L . reuteri DSM 17938 (1 × 10 8 colony forming units) or placebo daily for 28 days. We observed an overall reduction in median crying time, regardless of L . reuteri colonization status (n = 14 colonized). There were no differences in E . coli colonization rates or densities, microbial diversity or intestinal inflammation by L . reuteri colonization status. We found that L . reuteri density positively correlated with crying time, and E . coli density negatively correlated with microbial diversity. As density of L . reuteri was associated with increased crying time, L . reuteri supplementation may not be an appropriate treatment for all infants with colic.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-017-15404-7
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2017
detail.hit.zdb_id:
2615211-3
