In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2018-04-20)
Abstract:
Many human diseases are inflammation-related, such as cancer and those
associated with aging. Previous studies demonstrated that plasmon-induced activated (PIA) water with electron-doping character, created from hot electron transfer via
decay of excited Au nanoparticles (NPs) under resonant illumination, owns reduced hydrogen-bonded networks and physchemically antioxidative properties. In this study,
it is demonstrated PIA water dramatically induced a major antioxidative Nrf2 gene in human gingival fibroblasts which further
confirms its cellular antioxidative and anti-inflammatory properties. Furthermore, mice implanted with mouse Lewis lung carcinoma (LLC-1) cells drinking PIA water
alone or together with cisplatin treatment showed improved survival time compared to mice which consumed only deionized (DI) water. With the combination of PIA water and
cisplatin administration, the survival time of LLC-1-implanted mice markedly increased to 8.01 ± 0.77 days compared to 6.38 ± 0.61 days of mice given cisplatin
and normal drinking DI water. This sur vival time of 8.01 ± 0.77 days compared to
4.62 ± 0.71 days of mice just given normal drinking water is statistically significant ( p = 0.009). Also, the gross
observations and eosin staining results suggested that LLC-1-implanted mice drinking PIA water tended to exhibit less metastasis than mice given only DI water.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-018-24752-x
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2018
detail.hit.zdb_id:
2615211-3
