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    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2018-08-20)
    Abstract: Five sets of germacrane isomers ( 1 / 8/17 , 2 / 7/10/11/13/16/18 , 3 / 4/5/14/20 , 6 / 12/15 , and 9 / 19 ) with different skeletal types, including seven new ones ( 1 – 3 , 8 – 9 , and 15 – 16 ) were isolated from the whole plant of Carpesium divaricatum . Among them, there are six pairs of stereoisomers ( 1 / 8 , 2 / 13 , 4 / 14 , 6 / 12 , 7 / 11 and 10/11 ). The planar structures and relative configurations of the new compounds were elucidated by detailed spectroscopic analysis. The absolute configurations of 4 , 10 , 11 , and 17 were established by circular dichroism (CD) spectra and X-ray crystallographic analyses, and the stereochemistry of the new compounds 1 – 3 , 8 – 9 , and 15 – 16 were determined by similar CD spectra with 4 , 10 , 11 , and 17 , respectively. The confusion in the literature about subtypes I and II of germacranolides was clarified in this paper. The NMR data of 10 – 11 , and the absolute configurations of the known compounds 4 – 6 , 13 – 14 , and 17 – 20 were reported for the first time. Compounds 13 , 17 , and 18 showed cytotoxicity against human cervical (HeLa), colon (LoVo) and stomach cancer (BGC-823) cell lines with IC 50 values in the range 4.72–13.68  μ M compared with the control cis -platin (7.90–15.34  μ M).
    Type of Medium: Online Resource
    ISSN: 2045-2322
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 2615211-3
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