In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2018-10-31)
Abstract:
Using time-gated fluorescence lifetime imaging microscopy, significantly more signals from 3,6-bis(1-methyl-2-vinyl-pyridinium) carbazole diiodide ( o -BMVC) foci, characterized by the longer fluorescent decay time of o -BMVC, were detected in six types of cancer cells than in three types of normal cells. Accumulating evidence suggested that the o -BMVC foci are mainly the G-quadruplex foci. The large contrast in the number of o -BMVC foci can be considered as a common signature to distinguish cancer cells from normal cells. Further study of tissue biopsy showed that the o -BMVC test provides a high accuracy for clinical detection of head and neck cancers.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-018-34378-8
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2018
detail.hit.zdb_id:
2615211-3