In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2019-03-12)
Kurzfassung:
Helicobacter pylori infection is associated with high incidence of gastric diseases. The extensive therapy of H . pylori infection with antibiotics has increased its resistance rates worldwide. Ovatodiolide, a pure constituent isolated from Anisomeles indica , has been demonstrated to possess bactericidal activity against H . pylori . In this study, ovatodiolide inhibited the growth of both H . pylori reference strain and clinical multidrug-resistant isolates. Docking analysis revealed that ovatodiolide fits into the hydrophobic pocket of a ribosomal protein, RpsB. Furthermore, ovatodiolide inhibited bacterial growth by reducing levels of RpsB, which plays a crucial role in protein translation. Our results demonstrate that ovatodiolide binds to a ribosomal protein and interferes with protein synthesis. This study provides evidence that ovatodiolide has the potential to be developed into a potent therapeutic agent for treating H . pylori infection.
Materialart:
Online-Ressource
ISSN:
2045-2322
DOI:
10.1038/s41598-019-40735-y
Sprache:
Englisch
Verlag:
Springer Science and Business Media LLC
Publikationsdatum:
2019
ZDB Id:
2615211-3