In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2019-07-05)
Abstract:
Plasmodium infections in endemic areas are often asymptomatic, can be caused by different species and contribute significantly to transmission. We performed a cross-sectional study in February/March 2016 including 840 individuals ≥ 1 year living in rural Gabon (Ngounié and Moyen-Ogooué). Plasmodium parasitemia was measured by high-sensitive, real-time quantitative PCR. In a randomly chosen subset of P . falciparum infections, gametocyte carriage and prevalence of chloroquine-resistant genotypes were analysed. 618/834 (74%) individuals were positive for Plasmodium 18S-rRNA gene amplification, of these 553 (66.3%) carried P . falciparum , 193 (23%) P . malariae , 74 (8.9%) P . ovale curtisi and 38 (4.6%) P . ovale wallikeri . Non-falciparum infections mostly presented as mixed infections. P . malariae monoinfected individuals were significantly older (median age: 60 years) than coinfected (20 years) or P . falciparum monoinfected individuals (23 years). P . falciparum gametocyte carriage was confirmed in 109/223 (48.9%) individuals, prevalence of chloroquine-resistant genotypes was high (298/336, 89%), including four infections with a new SVMNK genotype. In rural Gabon, Plasmodium infections with all endemic species are frequent, emphasizing that malaria control efforts shall cover asymptomatic infections also including non-falciparum infections when aiming for eradication.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-019-46194-9
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2019
detail.hit.zdb_id:
2615211-3
