In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2019-11-11)
Abstract:
Recently, gold-coated magnetic nanoparticles have drawn the interest of researchers due to their unique magneto-plasmonic characteristics. Previous research has found that the magneto-optical Faraday effect of gold-coated magnetic nanoparticles can be effectively enhanced because of the surface plasmon resonance of the gold shell. Furthermore, gold-coated magnetic nanoparticles are ideal for biomedical applications because of their high stability and biocompatibility. In this work, we synthesized Fe 3 O 4 @Au core-shell nanoparticles and coated streptavidin (STA) on the surface. Streptavidin is a protein which can selectively bind to biotin with a strong affinity. STA is widely used in biotechnology research including enzyme-linked immunosorbent assay (ELISA), time-resolved immunofluorescence (TRFIA), biosensors, and targeted pharmaceuticals. The Faraday magneto-optical characteristics of the biofunctionalized Fe 3 O 4 @Au nanoparticles were measured and studied. We showed that the streptavidin-coated Fe 3 O 4 @Au nanoparticles still possessed the enhanced magneto-optical Faraday effect. As a result, the possibility of using biofunctionalized Fe 3 O 4 @Au nanoparticles for magneto-optical biomedical assays should be explored.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-019-52773-7
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2019
detail.hit.zdb_id:
2615211-3
