In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2020-06-22)
Abstract:
This study aimed to determine the association between serum uric acid (sUA) and nonalcoholic fatty liver disease (NAFLD) in nonobese postmenopausal women. A total of 4323 female individuals over 18 years of age participated in this cross-sectional study. The subjects were divided into four groups according to menopause status and body mass index. sUA quartiles in this female population were categorized as follows: Q1 ≤ 230 mmol/L, Q2: 231–270 mmol/L, Q3: 271–310 mmol/L and Q4: ≥ 311 mmol/L. The presence or absence of NAFLD was assessed by abdominal ultrasonography. The prevalence of NAFLD was 38.8% in the general population, and the average age was 46.5 ± 11.3 years. Among nonobese and obese subjects, the prevalence of NAFLD was lower in nonmenopausal subjects than in postmenopausal subjects (nonobese: 20.74% vs 45.26%, respectively, P 〈 0.0001; obese: 70.51% vs 84.35%, respectively, P 〈 0.0001). After adjusting for age, current smoking status, current alcohol drinking status, diabetes, hypertension disease and triglyceride, the ORs (95% CIs) for NAFLD among individuals in Q2-Q4 were 1.518 (1.062–2.169), 1.431 (1.010–2.027) and 2.054 (1.442–2.927), respectively, P value for trend 〈 0.0001. Higher sUA levels can be used as a predictive biomarker for NAFLD in nonobese postmenopausal women.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-020-66931-9
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2020
detail.hit.zdb_id:
2615211-3
