In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-11-25)
Abstract:
We aimed to evaluate whether a short distal resection margin ( 〈 1 cm) was associated with local recurrence in patients with locally advanced rectal cancer who underwent preoperative chemoradiotherapy. Patients with rectal cancer who underwent preoperative chemoradiotherapy followed by curative surgery were divided into two groups based on the distal resection margin (≥ 1 cm and 〈 1 cm). In total, 507 patients were analyzed. The median follow-up duration was 48.9 months. The 3-year local recurrence rates were 2% and 8% in the ≥ 1 cm and 〈 1 cm groups, respectively ( P 〈 0.001). Multivariable analysis revealed that a distal resection margin of 〈 1 cm was a significant risk factor for local recurrence ( P = 0.008). Subgroup analysis revealed that a distal resection margin of 〈 1 cm was not an independent risk factor for local recurrence in the ypT0–1 group. However, among patients with tumor stages ypT2–4, the cumulative 3-year incidences of local recurrence were 2.3% and 9.8% in the ≥ 1 cm and 〈 1 cm groups, respectively ( P = 0.01). A distal resection margin of 〈 1 cm might influence local recurrence rates in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy, especially in patients with tumor stages ypT2–4.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-021-02438-1
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2021
detail.hit.zdb_id:
2615211-3
