In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-08-27)
Abstract:
This study was aimed to compare the vascular healing process of a SYNERGY stent with that of a PROMUS PREMIER stent in patients with acute coronary syndrome (ACS). In 71 patients with ACS, undergoing coronary stent implantation using the SYNERGY stent (n = 52) or PROMUS PREMIER stent (n = 19), we measured circulating CD34+/CD133+/CD45 null cells and CD34+/KDR+ cells and observed vascular healing at the stented sites using optical coherence tomography (OCT) and coronary angioscopy. On the day 7, circulating CD34+/CD133+/CD45 null cells increased in SYNERGY group ( P 〈 0.0001), while it did not change in PROMUS group. The CD34+/KDR+ cells also increased in SYNERGY group ( P 〈 0.0001) but less significantly in the PROMUS group ( P 〈 0.05). The OCT-based neointimal thickness ( P 〈 0.0005) and neointimal coverage rate ( P 〈 0.05) at 12 months were greater in SYNERGY group, compared with PROMUS group. The coronary angioscopy-based neointimal coverage grade at 12 months was also greater in SYNERGY group ( P 〈 0.001). In overall patients, the change in CD34+/KDR+ cells on the day 7 correlated with the OCT-based neointimal thickness at 12 months (R = 0.288, P 〈 0.05). SYNERGY stent seems to have potential advantages over PROMUS PREMIER stent for ACS patients in terms of vascular healing process at the stented sites.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-021-96730-9
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2021
detail.hit.zdb_id:
2615211-3
