In:
Dalton Transactions, Royal Society of Chemistry (RSC), Vol. 50, No. 42 ( 2021), p. 15389-15399
Kurzfassung:
Reaction between [RuCl 2 (CO) 2 ] n and 1 H -benzimidazol-2-ylmethyl-( N -phenyl)amine ligands (L R ) functionalized with various electron-donating and electron-withdrawing substituents on the phenyl ring (R = H, 4-CH 3 , 4-Cl, 4-COOCH 3 , and 3-COOCH 3 ) afforded the dark-stable photoactivatable carbon monoxide prodrugs of the general formula [RuCl 2 (CO) 2 L R ]. Release of the CO molecules from the Ru( ii ) compounds was examined by monitoring the electronic and IR spectra upon illumination at 365 nm. A noticeable decrease in the intensities of the two characteristic ν (CO) modes for Ru(CO)II2 species, and the growth of two new bands for the mono-carbonyl species and free CO, were the main features of the photolysis profiles. The cytotoxicity of the complexes towards breast cancer (MCF-7) cells was assessed with and without illumination at 365 nm. All the complexes except that with a 4-COOCH 3 group (IC 50 = 45.08 ± 3.5 μM) are nontoxic under dark conditions. Upon illumination, all the compounds acquired cytotoxicity in the following order: H 〉 4-COOCH 3 〉 4-CH 3 〉 4-Cl 〉 3-COOCH 3 . Investigation of the cytotoxicity of the CO-depleted fragments showed that the light-induced cytotoxicity can be attributed to the liberated CO and CO-depleted metal fragments, including the liberated benzimidazole ligands.
Materialart:
Online-Ressource
ISSN:
1477-9226
,
1477-9234
Sprache:
Englisch
Verlag:
Royal Society of Chemistry (RSC)
Publikationsdatum:
2021
ZDB Id:
1472887-4
