In:
Materials Advances, Royal Society of Chemistry (RSC), Vol. 3, No. 2 ( 2022), p. 1191-1199
Abstract:
Chemodynamic therapy (CDT) is an emerging strategy of tumor therapy that utilizes the Fenton reagent to kill tumor cells by disproportionation of H 2 O 2 into hydroxyl radical (˙OH). However, insufficient endogenous H 2 O 2 confines the antitumor efficacy of CDT. Additionally, the overexpressed glutathione (GSH) exhibits a potent scavenging effect on cytotoxic ˙OH, which further diminishes the efficacy of CDT. Though tremendous efforts have been done, engineering CDT agents with efficient and specific H 2 O 2 self-supplying and GSH-depletion is promising but remains a great challenge. Herein, Fe 3+ –chelated CaO 2 nanoparticles (CaO 2 –Fe NPs) are constructed as ROS ‘bomb’. In the tumor microenvironment, CaO 2 –Fe NPs can release Fe 2+ by the reduction of GSH, and the remaining CaO 2 reacts with H + to selectively generate H 2 O 2 . The generated H 2 O 2 can produce ˙OH under the catalysis of Fe 2+ through the Fenton reaction, and re-oxidation from Fe 2+ to Fe 3+ endowing a long-lasting GSH-depletion, resulting in an improved CDT. These CaO 2 –Fe NPs supply H 2 O 2 and exhaust GSH simultaneously to achieve a self-enhanced CDT, and paves an emerging strategy to enhance the therapeutic efficacy of CDT by combining H 2 O 2 -replenishable and GSH-depletive together and realizing a self-enhanced Fenton reaction cycle.
Type of Medium:
Online Resource
ISSN:
2633-5409
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022
detail.hit.zdb_id:
3031236-X
