In:
New Journal of Chemistry, Royal Society of Chemistry (RSC), Vol. 46, No. 2 ( 2022), p. 592-598
Abstract:
An efficient one-pot four-component reaction for the synthesis of a new family of novel bridgehead nitrogen-containing pyrido[1,2- d ][1,4] diazepines has been described and its mechanism has been proposed, which follows a ring-closure and ring-cleavage pathway. The protocol involved a cyclization through γ -selective C–C bond formation, an intramolecular Michael addition and a ring-opening of a pyranone ring under refluxing conditions with high to excellent yields. The advantages of this methodology, including the use of easily available raw materials and an inexpensive catalyst, an open-air reaction setup, wide functional group tolerance, and gram-scale synthesis, make the developed methodology a practical way to access novel pyrido[1,2- d ][1,4] diazepines and functionalized tricyclic or polycyclic fused 1,4-diazepines as well as novel analogs of important biologically active molecules.
Type of Medium:
Online Resource
ISSN:
1144-0546
,
1369-9261
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022
detail.hit.zdb_id:
1472933-7