In:
Nanoscale, Royal Society of Chemistry (RSC), Vol. 13, No. 37 ( 2021), p. 15569-15575
Kurzfassung:
Near-infrared two-zone (NIR-II) fluorescence imaging has attracted attention as a non-invasive imaging technology that provides centimeter-level depth and micron-level resolution. However, producing a NIR-II fluorescent nanoprobe with uniform size, high bio-identical capacity, and fluorescence intensity, while being metabolizable in vivo , remains a challenge. We first produce a hydrophobic NIR-II fluorescent molecule with AIE properties, and subject it to ultrasonic and extrusion treatments to generate a DSPE-PEG-encapsulated NIR-II nanoprobe with an ultra-homogeneous particle size. The current study based on in vitro and mouse tumor-bearing model-based experiments indicate that cancer cells could efficiently take up this nanoprobe, which aggregates in tumor tissues, is susceptible to metabolization, and enables ideal photothermal therapeutic effects. Thus, this NIR-II nanoprobe with AIE properties shows great potential for precise clinical diagnosis and treatment of cancer.
Materialart:
Online-Ressource
ISSN:
2040-3364
,
2040-3372
Sprache:
Englisch
Verlag:
Royal Society of Chemistry (RSC)
Publikationsdatum:
2021
ZDB Id:
2515664-0