In:
Organic Chemistry Frontiers, Royal Society of Chemistry (RSC), Vol. 9, No. 3 ( 2022), p. 764-770
Kurzfassung:
The first enantioselective synthesis of axially chiral styrene-type allylamines was achieved through chiral phosphoric acid mediated atroposelective reductive amination of 1-enal substituted 2-naphthols. This protocol features a broad substrate scope, good enantioselectivities (up to 90% ee) and mild reaction conditions, thus providing a new entry to the challenging atropisomeric acyclic styrene scaffolds.
Materialart:
Online-Ressource
ISSN:
2052-4129
Sprache:
Englisch
Verlag:
Royal Society of Chemistry (RSC)
Publikationsdatum:
2022