In:
Soft Matter, Royal Society of Chemistry (RSC), Vol. 17, No. 32 ( 2021), p. 7516-7523
Kurzfassung:
Here we present a pH-responsive self-assembly based on a β-cyclodextrin (β-CD) derivative bearing a dansyl terminus (βCD-C 6 –Dns). Vesicular structures were formed over the entire studied pH range (8.5–0.7); however, the molecular configuration and packing within the vesicles were different at different pH values. Intramolecular host–guest complexation occurred mainly between the dansyl group and β-CD at pH values where the dansyl group was not protonated. The alkyl chain also acted as a competitive guest to form host–guest inclusions as confirmed by 2D 1 H NMR measurements. The pH-responsive βCD-C 6 –Dns vesicles have potential application prospects in pH-controlled drug release based on the low cytotoxicity of βCD-C 6 –Dns.
Materialart:
Online-Ressource
ISSN:
1744-683X
,
1744-6848
Sprache:
Englisch
Verlag:
Royal Society of Chemistry (RSC)
Publikationsdatum:
2021
ZDB Id:
2191476-X
