In:
Chemical Communications, Royal Society of Chemistry (RSC), Vol. 58, No. 46 ( 2022), p. 6653-6656
Kurzfassung:
A Cu-catalyzed asymmetric 1,6-conjugate addition of in situ generated para -quinone methides ( p -QMs) with β-ketoester has been developed to construct a ketoester skeleton bearing an adjacent tertiary–quaternary carbon stereocenter in good yields and high enantioselectivities. This is the first example of metal-catalyzed asymmetric transformations of the in situ generated p -QMs, avoiding using pre-synthesized p -QMs requiring bulky 2,6-substitutions and highlighting a new dual catalytic activation with the chiral bis(oxazoline)–metal complex acting as a normal Lewis acid to activate the β-ketoesters and a source of Brønsted acid responsible for generating the p -QMs in situ .
Materialart:
Online-Ressource
ISSN:
1359-7345
,
1364-548X
Sprache:
Englisch
Verlag:
Royal Society of Chemistry (RSC)
Publikationsdatum:
2022
ZDB Id:
1472881-3