In:
Organic Chemistry Frontiers, Royal Society of Chemistry (RSC), Vol. 9, No. 11 ( 2022), p. 3093-3101
Abstract:
(±)-Spiroganoapplanin A (1) representing a new subtype of the Ganoderma meroterpenoid dimer with a 6/5/5/6/5/6 hexacyclic system was isolated from Ganoderma applanatum . Using spectroscopic, X-ray crystallographic and electronic circular dichroism analyses, the structure of the racemic natural product was determined, and its unusual NMR behavior was investigated by variable-temperature NMR experiments. The possible biogenetic pathway for 1 was proposed. Cellular assays showed that (±)-1, (+)-1, and (−)-1 all reduce Aβ42 production and inhibit tau phosphorylation through BACE1, CDK5, and GSK3β-mediated pathways, suggesting their potential against Alzheimer's disease.
Type of Medium:
Online Resource
ISSN:
2052-4129
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022
