In:
Organic Chemistry Frontiers, Royal Society of Chemistry (RSC), Vol. 9, No. 17 ( 2022), p. 4705-4711
Kurzfassung:
The asymmetric synthesis of the marine meroterpenoid dactyloquinone A was accomplished for the first time. The key advanced intermediate, a 6/6/6/6 tetracyclic core derivative, was constructed by a bio-inspired Lewis acid-catalyzed cyclization reaction, which drove the migration of the methyl groups of two different configurations at the C-4 site by 1,2-rearrangement from the aureane skeleton to the avarane skeleton. This strategy sets the stage for the synthetic exploration of other members of this family of natural products.
Materialart:
Online-Ressource
ISSN:
2052-4129
Sprache:
Englisch
Verlag:
Royal Society of Chemistry (RSC)
Publikationsdatum:
2022
