In:
Chemical Communications, Royal Society of Chemistry (RSC), Vol. 59, No. 35 ( 2023), p. 5213-5216
Abstract:
Bicyclo[1.1.1]pentanes (BCPs) represent an important compound class often used as linear spacer units to enhance pharmacokinetic profiles in modern drug design. Herein, we report a cascade multicomponent reaction to synthesize gem -difluoroallylic bicyclo[1.1.1]pentanes via visible light-induced defluorinative gem -difluoroallylation of [1.1.1]propellane. In this methodology, sulfonyl radicals generated from sodium arylsulfinates added to [1.1.1] propellane to form BCP radicals were then trapped by α-trifluoromethyl alkenes to form gem -difluoroallylic bicyclo[1.1.1]pentanes. Importantly, our methodology is characterized by mild reaction conditions, wide reactant scope, and suitable functional group tolerance.
Type of Medium:
Online Resource
ISSN:
1359-7345
,
1364-548X
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2023
detail.hit.zdb_id:
1472881-3