In:
Biochemical Society Transactions, Portland Press Ltd., Vol. 45, No. 1 ( 2017-02-08), p. 173-181
Abstract:
Given its importance in development and homeostasis, bone morphogenetic protein (BMP) signaling is tightly regulated at the extra- and intracellular level. The extracellular matrix (ECM) was initially thought to act as a passive mechanical barrier that sequesters BMPs. However, a new understanding about how the ECM plays an instructive role in regulating BMP signaling is emerging. In this mini-review, we discuss various ways in which the biochemical and physical properties of the ECM regulate BMP signaling.
Type of Medium:
Online Resource
ISSN:
0300-5127
,
1470-8752
Language:
English
Publisher:
Portland Press Ltd.
Publication Date:
2017
SSG:
12