In:
British Journal of Haematology, Wiley, Vol. 100, No. 4 ( 1998-03), p. 728-734
Abstract:
Dysregulation of T‐cell receptor (TCR) αβ bearing lymphocytes and an increase in Vδ1 + γδ T cells are typical features of HIV‐1 infection. However, the role of γδ T cells remains unclear. Therefore, peripheral blood mononuclear cells (PBMC) of 103 HIV‐1‐infected patients were investigated with respect to expression of Vδ1. These results were compared to the Vδ1 expression of bone marrow mononuclear cells (BMMC). In contrast to healthy controls, Vδ1 + cells dominated among both PBMC and BMMC in HIV‐1‐infected patients. Analysis of the coexpression of CD25, CD8, HLA‐DR and CD45RO revealed a high prevalence of Vδ1/CD45RO and Vδ1/HLA‐DR double‐positive PBMC only in HIV‐1‐infected patients but not in healthy donors. Furthermore, analysis of the γδ TCR repertoire in patients infected with hepatitis B virus, hepatitis C virus, herpes simplex virus (HSV)‐1 and HSV‐2 showed that the selective enhancement of Vδ1 + cells was restricted to HIV infection and not observed in other virus diseases. Our data provide further support for the involvement of γδ T cells in immunosuppression and progression of HIV infection.
Type of Medium:
Online Resource
ISSN:
0007-1048
,
1365-2141
DOI:
10.1046/j.1365-2141.1998.00630.x
Language:
English
Publisher:
Wiley
Publication Date:
1998
detail.hit.zdb_id:
1475751-5