In:
Pathology International, Wiley, Vol. 50, No. 12 ( 2000-12), p. 973-978
Abstract:
A case of carcinosarcoma of the urinary bladder in a 2‐year‐old girl is reported. The tumor, measuring 34 × 20 × 18 mm, was located in the peri‐trigone area of the urinary bladder with polypoid features. Histologic examination revealed transitional cell carcinoma at the tumor surface with downward invasion. Concurrently, a sarcomatous area was found beneath the carcinoma, with these two different malignant components sharing on apparent transition without dis‐tinct boundaries. Sarcomatous components included immature round cells focally showing rhabdoid features. No rhabdomyomatous component was observed. Immunohistochemistry disclosed vimentin and cytokeratin‐double positive cells at the transposition between carcinoma and sarcomatous components. In addition, ultrastructural analysis revealed that the epithelial cells had a distinct junctional complex, and the sarcomatous cells occasionally had a meshwork of cytoplasmic intermediate filaments, indicat‐ing bidirectional cytodifferentiation to epithelial and mesenchymal elements. The extremely young age at which this case of carcinosarcoma occurred suggests that the tumor may be of mesodermal stem cell origin.
Type of Medium:
Online Resource
ISSN:
1320-5463
,
1440-1827
DOI:
10.1046/j.1440-1827.2000.01135.x
Language:
English
Publisher:
Wiley
Publication Date:
2000
detail.hit.zdb_id:
2008574-6