In:
médecine/sciences, EDP Sciences, Vol. 36, No. 10 ( 2020-10), p. 893-899
Kurzfassung:
Non-infectious uveitis is a heterogenous group of potentially blinding ocular autoimmune diseases that may represent a manifestation of a systemic condition or may affect the eyes only. A systemically administered anti-TNF has recently been approved for the treatment of non-infectious uveitis, broadening the therapeutic arsenal available to control intraocular inflammation and reduce uveitis complications that can lead to vision loss. When uveitis affects only the eyes, a local anti-TNF-α administration strategy could optimize the ocular therapeutic effect and reduce undesirable systemic side-effects. A new ocular method of non-viral gene therapy, currently in development, may broaden the indications for ocular anti-TNF-α agents, not only for uveitis but also for other diseases in which TNF-α-mediated neuro-inflammation has been demonstrated.
Materialart:
Online-Ressource
ISSN:
0767-0974
,
1958-5381
DOI:
10.1051/medsci/2020160
Sprache:
Französisch
Verlag:
EDP Sciences
Publikationsdatum:
2020
ZDB Id:
2049442-7
