In:
Drug Research, Georg Thieme Verlag KG, Vol. 73, No. 05 ( 2023-06), p. 255-262
Kurzfassung:
Renal ischemia-reperfusion injury (IRI) is considered as one of the most
prevalent causes of acute kidney injury (AKI), which can happen in various clinical situations including hypovolemic shock, injury, thrombo-embolism, and
after a kidney transplant. This paper aims to evaluate the reno-protective effects of Quercetin in induced ischemia/reperfusion injury by
regulating apoptosis-related proteins, inflammatory cytokines, MMP-2, MMP-9, and nuclear factor kappa-light-chain-enhancer inactivated B cells (NF-kB) in rats.
The male Wistar rats (n=32) were randomly divided into Sham, untreated IR, and Quercetin-treated IR (gavage and intraperitoneal). Quercetin was given
orally and intraperitoneally one hour before inducing ischemia-reperfusion injury . After reperfusion, blood samples and kidneys were collected to assess
renal function and inflammatory cytokines, apoptotic signaling proteins, and antioxidants. Urea, creatinine, and MDA levels improved in Quercetin-treated
groups with different administration methods. In addition, the activities of other antioxidant in Quercetin-treated rats were higher than those in the IR
group. Further, Quercetin inhibited NF-kB signaling, apoptosis-associated factors and produced matrix metalloproteinase protein in the kidneys of rats.
Based on the findings, the antioxidant, anti-inflammatory, and anti-apoptotic effects of the Quercetin diminished renal ischemia-reperfusion injury in the rats significantly. It is suggested that a single dosage of Quercetin have a
reno-protective impact in the case of renal I/R injury.
Materialart:
Online-Ressource
ISSN:
2194-9379
,
2194-9387
Sprache:
Englisch
Verlag:
Georg Thieme Verlag KG
Publikationsdatum:
2023
SSG:
15,3
