In:
Hormone and Metabolic Research, Georg Thieme Verlag KG, Vol. 55, No. 10 ( 2023-10), p. 733-740
Abstract:
The etiopathogenesis of metabolic syndrome (MetS) has not been fully understood
yet, and chronic low-grade inflammation is thought to be associated with the development of complications related to MetS. We aimed to investigate the role
of Nuclear factor Kappa B ( NF-κB ), Peroxisome Proliferator-Activated Receptor- α and γ (PPAR-α, and PPAR-γ) which are
the main markers of inflammation in older adults with MetS. A total of 269 patients aged≥18, 188 patients with MetS who met the diagnostic criteria
of the International Diabetes Federation, and 81 controls who applied to geriatrics and general internal medicine outpatient clinics for various reasons
were included in the study. Patients were separated into four groups: young with MetS ( 〈 60, n=76), elderly with MetS (≥60,
n=96), young control ( 〈 60, n=31), elderly
controls (≥60, n=38). Carotid intima-media thickness (CIMT) and NF-κB , PPAR-α, and PPAR-γ plasma levels were measured
in all of the participants. Age and sex distribution were similar between MetS and control groups. C-reactive protein (CRP), NF-κB levels
(p=0.001) and CIMT (p 〈 0,001) of MetS group were significantly
higher than in the control groups. On the other hand, the PPAR-γ (p=0.008) and PPAR-α (p=0.003) levels were significantly
lower in MetS. ROC analysis revealed that the NF-κB, PPAR-α, and PPAR-γ could be used to indicate MetS in younger adults (AUC: 0.735,
p 〈 0.000; AUC: 0.653, p=0.003), whereas it could not be an
indicator in older adults (AUC: 0.617, p=0.079; AUC:0.530, p=0.613). It seems that these markers have important roles in
MetS-related inflammation. In our results, suggest that the indicator feature of NF-κB , PPAR-α and PPAR-γ in recognizing MetS in young
individuals is lost in older adults with Mets.
Type of Medium:
Online Resource
ISSN:
0018-5043
,
1439-4286
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2023
detail.hit.zdb_id:
2056576-8
