In:
Synthesis, Georg Thieme Verlag KG, Vol. 51, No. 19 ( 2019-10), p. 3709-3714
Abstract:
The Beckmann rearrangement (BKR) of ketones to secondary amides often requires harsh reaction conditions that limit its practicality and scope. Herein, the Cu(OTf)2-catalyzed BKR of ketones under mild reaction conditions using hydroxylamine-O-sulfonic acid (HOSA), a commercial water soluble aminating agent, is described. This method is compatible with most functional groups and directly provides the desired amides in good to excellent yields.
Type of Medium:
Online Resource
ISSN:
0039-7881
,
1437-210X
DOI:
10.1055/s-0039-1690005
Language:
German
Publisher:
Georg Thieme Verlag KG
Publication Date:
2019
detail.hit.zdb_id:
204080-3
detail.hit.zdb_id:
2033062-5
