In:
Planta Medica, Georg Thieme Verlag KG, Vol. 84, No. 01 ( 2018-01), p. 49-58
Abstract:
Phytochemical investigation of the leaves and twigs of Lithocarpus litseifolius and Lithocarpus corneus resulted in the isolation of four new triterpenoids (1–4), three triterpenoids (5–7) isolated from a natural source for the first time, and six known compounds (8–13). In addition, four known triterpenoids (14–17) were isolated from L. corneus. Compound 1 is a 3,4-seco-lupane-type triterpenoid, and compounds 2–4 are lupane-type triterpenoids in different oxidation states. The structures of all isolated compounds were identified by spectroscopic methods, especially NMR and mass spectrometry data. The absolute configuration of 2 and 3 was confirmed by X-ray single crystallographic analysis. The anti-inflammatory activities of 1–17 and anti-HIV activities of 2–17 were evaluated. Among them, 3-epi-betulinic acid (8) showed a strong anti-HIV activity comparable to abacavir, a drug used for treating HIV/AIDS. 3,4-seco-4(23),20(29)-lupadiene-3,28-dioic acid (5) exhibited potent inhibition of superoxide-anion generation with 86.9 ± 2.8% inhibition at 1 µM.
Type of Medium:
Online Resource
ISSN:
0032-0943
,
1439-0221
DOI:
10.1055/s-0043-113826
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2018
detail.hit.zdb_id:
2037089-1
SSG:
15,3