In:
Australian Journal of Chemistry, CSIRO Publishing, Vol. 69, No. 4 ( 2016), p. 363-
Abstract:
The synthesis and gene transfection efficiency of a series of amphiphilic copolymers, poly(2-(dimethylamino)ethyl methacrylate)-poly (methacrylate isobutyl polyhedral oligomeric silsesquioxane) (PDMAEMA-POSS) copolymers are reported. The hydrophobic POSS interior allows a cell-sensitizing drug such as paclitaxel to be incorporated, whereas the cationic and hydrophilic PDMAEMA corona allows the complexation of anionic DNA to form a nano-sized polyplex. These drug-encapsulated copolymers display excellent gene transfection efficiency compared with polyethylenimine or PDMAEMA homopolymers.
Type of Medium:
Online Resource
ISSN:
0004-9425
Language:
English
Publisher:
CSIRO Publishing
Publication Date:
2016