In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 98, No. 10 ( 2001-05-08), p. 5827-5832
Kurzfassung:
Nonlinear-dynamical control techniques, also known as chaos
control, have been used with great success to control a wide range of physical systems. Such techniques have been used to control the
behavior of in vitro excitable biological tissue,
suggesting their potential for clinical utility. However, the feasibility of using such techniques to control physiological processes
has not been demonstrated in humans. Here we show that nonlinear-dynamical control can modulate human cardiac
electrophysiological dynamics by rapidly stabilizing an unstable target rhythm. Specifically, in 52/54 control attempts in five patients, we
successfully terminated pacing-induced period-2 atrioventricular-nodal conduction alternans by stabilizing the underlying unstable
steady-state conduction. This proof-of-concept demonstration shows that nonlinear-dynamical control techniques are clinically feasible and
provides a foundation for developing such techniques for more complex forms of clinical arrhythmia.
Materialart:
Online-Ressource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.091553398
Sprache:
Englisch
Verlag:
Proceedings of the National Academy of Sciences
Publikationsdatum:
2001
ZDB Id:
209104-5
ZDB Id:
1461794-8
SSG:
11
SSG:
12
