In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 98, No. 20 ( 2001-09-25), p. 11497-11502
Kurzfassung:
Despite the widespread use of bacillus Calmette–Guérin
vaccination, Mycobacterium tuberculosis infection
remains globally the leading cause of death from a single infectious disease. The complicated and often protracted dynamics of infection and
disease make clinical trials to test new tuberculosis vaccines extremely complex. Preclinical selection of only the most promising
candidates is therefore essential. Because macaque monkeys develop a disease very similar to humans, they have potential to provide
important information in addition to small animal models. To assess the relative merits of rhesus and cynomolgus monkeys as screens for
tuberculosis vaccines, we compared the efficacy of bacillus Calmette–Guérin vaccination and the course of infection in both
species. Unvaccinated rhesus and cynomolgus monkeys both developed progressive disease with high levels of C-reactive protein, M.
tuberculosis -specific IgG, and extensive pathology including
cavitation and caseous necrosis. Bacillus Calmette–Guérin vaccination protected cynomolgus almost completely toward the
development of pathology, reflected in a striking 2-log reduction in viable bacteria in the lungs compared with nonvaccinated animals.
Rhesus, on the other hand, were not protected efficiently by the bacillus Calmette–Guérin. The vaccinated animals developed
substantial pathology and had negligible reductions of colony-forming units in the lungs. Comparative studies in these closely related
species are likely to provide insight into mechanisms involved in protection against tuberculosis.
Materialart:
Online-Ressource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.201404898
Sprache:
Englisch
Verlag:
Proceedings of the National Academy of Sciences
Publikationsdatum:
2001
ZDB Id:
209104-5
ZDB Id:
1461794-8
SSG:
11
SSG:
12