In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 97, No. 21 ( 2000-10-10), p. 11569-11574
Kurzfassung:
The neuropeptide galanin colocalizes with choline
acetyltransferase, the synthetic enzyme for acetylcholine, in a subset of cholinergic neurons in the basal forebrain of rodents. Chronic
intracerebroventricular infusion of nerve growth factor induces a 3- to 4-fold increase in galanin gene expression in these neurons. Here we
report the loss of a third of cholinergic neurons in the medial septum and vertical limb diagonal band of the basal forebrain of adult mice
carrying a targeted loss-of-function mutation in the galanin gene. These deficits are associated with a 2-fold increase in the number of
apoptotic cells in the forebrain at postnatal day seven. This loss is associated with marked age-dependent deficits in stimulated
acetylcholine release, performance in the Morris water maze, and induction of long-term potentiation in the CA1 region of the
hippocampus. These data provide unexpected evidence that galanin plays a trophic role to regulate the development and function of a subset of
septohippocampal cholinergic neurons.
Materialart:
Online-Ressource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.210254597
Sprache:
Englisch
Verlag:
Proceedings of the National Academy of Sciences
Publikationsdatum:
2000
ZDB Id:
209104-5
ZDB Id:
1461794-8
SSG:
11
SSG:
12
