In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 97, No. 25 ( 2000-12-05), p. 13812-13817
Abstract:
To test the hypothesis that β-chemokine levels may be relevant to the control of HIV in vivo , we compared RANTES, MIP-1α, and MIP-1β production from purified CD8 + T cells from 81 HIV-infected subjects and from 28 uninfected donors. Asymptomatic HIV + subjects produced significantly higher levels of MIP-1α and MIP-1β, but not RANTES, than uninfected donors or patients that progressed to AIDS. In contrast, β chemokines in plasma were either nondetectable or showed no correlation with clinical status. The high β-chemokine-mediated anti-HIV activity was against the macrophage tropic isolate HIV-1 BAL , with no demonstrable effect on the replication of the T-cell tropic HIV-1 IIIB . These findings suggest that constitutive β-chemokine production may play an important role in the outcome of HIV-1 infection.
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.240469997
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
2000
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12