In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 68, No. 3 ( 1971-03), p. 662-666
Abstract:
Rats received intracisternal [ 3 H]norepinephrine and, after 5 min, intraperitoneal L-dopa (100 mg/kg); they were killed at intervals during the subsequent 24 hr. Their brains were assayed for norepinephrine, L-dopa, S -adenosylmethionine, and [ 3 H]norepinephrine and its metabolites. Rats that received L-dopa had markedly lower brain concentrations of S -adenosylmethionine and of O -methylated metabolites of [ 3 H]norepinephrine than controls. An increase (15-40%) in brain norepinephrine content and accelerated turnover of brain norepinephrine was also observed in the animals receiving L -dopa. These changes were all transient, lasting about 1 hr and coinciding with the period when appreciable amounts of L-dopa were detectable in the brain.
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.68.3.662
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
1971
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12
