In:
Bioscience, Biotechnology, and Biochemistry, Informa UK Limited, Vol. 78, No. 3 ( 2014-03-04), p. 482-489
Kurzfassung:
A Vigna nakashimae (VN) extract has been shown to have antidiabetic and anti-obesity effects. However, the mechanism underlying the effect of a VN extract on hepatic inflammation and endoplasmic reticulum (ER) stress remains unclear. In the present study, we investigated how a VN extract protects against the development of non-alcoholic fatty liver disease (NAFLD). A VN extract for 12 weeks reduced the body weight, serum metabolic parameters, cytokines, and hepatic steatosis in high-fat diet (HFD)-fed mice. A VN extract decreased HFD-induced hepatic acetyl CoA carboxylase and glucose transporter 4 expressions. In addition to the levels of high-mobility group box 1 and receptor for advanced glycation, the hepatic expression of ATF4 and caspase-3 was also reduced by a VN extract. Thus, these data indicate that a chronic VN extract prevented NAFLD through multiple mechanisms, including inflammation, ER stress, and apoptosis in the liver.
Materialart:
Online-Ressource
ISSN:
0916-8451
,
1347-6947
DOI:
10.1080/09168451.2014.882753
Sprache:
Englisch
Verlag:
Informa UK Limited
Publikationsdatum:
2014
ZDB Id:
2110940-0
SSG:
12
