In:
Sarcoma, Hindawi Limited, Vol. 6, No. 3 ( 2002), p. 105-110
Kurzfassung:
Purpose: Leiomyosarcomas (LMS) of deep and superficial tissues were examined to identify prognostic markers explaining
their different biological behaviour and to define differences between cutaneous and subcutaneous LMS. LMS and leiomyomas (LM) of the skin were compared to and consistent differences that could aid in the (sometimes difficult) diagnosis. Patients: Material was obtained from 27 patients with a deep LMS, 14 with a superficial LMS, and 21 with a LM. Methods: Proliferation markers (mitotic and Ki-67 indices), DNA ploidy, size, grade, and the amount of apoptosis were
studied. Statistical analysis was performed and survival curves were constructed by the Kaplan-Meier method and compared by the log-rank test. Results: Superficial LMS were smaller than deep LMS (p 〈 0.05), and the overall survival of patients with a superficial LMS
was better than with a deep LMS (p 〈 0.05).Within the group of superficial LMS only entirely subcutaneous, and not cutaneous
tumors metastasized.No differences were found in the other examined parameters. Proliferation and apoptotic indices were significantly higher in superficial LMS compared to superficial LM. Discussion: The difference in clinical outcome between patients with a superficial and deep LMS, seems to be related to site
and size.The metastatic potential of subcutaneous LMS, however, seems to be related to location alone and not to size.The amount of apoptosis and proliferation can be used as additional criteria in the differentiation between superficial LMS and
LM.
Materialart:
Online-Ressource
ISSN:
1357-714X
,
1369-1643
DOI:
10.1080/1357714021000065404
Sprache:
Englisch
Verlag:
Hindawi Limited
Publikationsdatum:
2002
ZDB Id:
2011839-9
