In:
The Journal of Cell Biology, Rockefeller University Press, Vol. 180, No. 2 ( 2008-01-28), p. 267-272
Abstract:
Over the past decade, many of the key components of the genetic machinery that regulate the asymmetric division of Drosophila melanogaster neural progenitors, neuroblasts, have been identified and their functions elucidated. Studies over the past two years have shown that many of these identified components act to regulate the self-renewal versus differentiation decision and appear to function as tumor suppressors during larval nervous system development. In this paper, we highlight the growing number of molecules that are normally considered to be key regulators of cell cycle events/progression that have recently been shown to impinge on the neuroblast asymmetric division machinery to control asymmetric protein localization and/or the decision to self-renew or differentiate.
Type of Medium:
Online Resource
ISSN:
1540-8140
,
0021-9525
DOI:
10.1083/jcb.200708159
Language:
English
Publisher:
Rockefeller University Press
Publication Date:
2008
detail.hit.zdb_id:
1421310-2
SSG:
12
